A1.2.6 DNA as a double helix linked by hydrogen bonding between complementary base pairs
A1.2.6 DNA as a double helix linked by hydrogen bonding between complementary base pairs Notes
DNA Consists Of Two Polynucleotide Strands
Each strand has a sugar–phosphate backbone with nitrogenous bases projecting inward.
The strands align side by side, forming a double-stranded structure.
DNA as a double helix
The Antiparallel Arrangement of DNA Strands
The two DNA strands run in opposite directions.
One strand runs 5′ to 3′, while the other runs 3′ to 5′.
This arrangement is called antiparallel.
Drawing the Structure of DNA
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Questions
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Question 1
Recap question
Which type of interaction between complementary bases provides both sufficient stability in the double helix and the ability to separate strands during replication?
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Note
DNA as a Double Helix
DNA is a double helix, meaning it consists of two intertwined strands that form a spiral structure.
The two strands are held together by hydrogen bonds between specific pairs of nitrogenous bases.
This structure was first discovered by Watson and Crick in 1953.
AnalogyThink of the DNA double helix like a twisted ladder, where the sugar-phosphate backbones are the sides of the ladder and the base pairs are the rungs.