Notes for D1.1.7 Differences between replication on the leading strand and the lagging strand (HL) - IB | RevisionDojo
D1.1.7 Differences between replication on the leading strand and the lagging strand (HL) Notes
Differences Between Replication on the Leading Strand and the Lagging Strand
DNA polymerase, the enzyme responsible for synthesizing new DNA, can only add nucleotides in the 5′ to 3′ direction.
This creates two distinct replication processes:
Continuous replication on the leading strand and discontinuous replication on the lagging strand.
Continuous and discontinuous replicationNote
DNA strands run in opposite directions, one in the 5′ to 3′direction and the other in the 3′ to 5′direction.
Continuous Replication on the Leading Strand
The leading strand is synthesized in the same direction as the replication fork's movement.
Single Primer Initiation: DNA primase adds an RNA primer at the start of the strand.
Continuous Synthesis: DNA polymerase III adds nucleotides without interruption, creating a smooth, unbroken strand.
Tip
Think of the leading strand as a car driving on a straight highway, moving steadily without stops.
Discontinuous Replication on the Lagging Strand
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Questions
Recap questions
1 of 5
Question 1
Recap question
At a replication fork moving to the right, the top parental strand runs 5′→3′ from left to right. Which daughter strand will be synthesized continuously?
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In which direction can DNA polymerase add nucleotides?
